CITREGEN Technology
®
Inspired by nature, CITREGEN is a paradigm-changing synthetic biomaterial purposefully designed on a molecular level to replicate the intrinsic cellular support network. CITREGEN's main component, citrate, is historically known as a naturally occurring metabolic molecule but has recently been shown to play important roles in bone anatomy.
CITREGEN Mechanism of Action
CITREGEN resorption begins with polymer hydrolysis releasing citrate, calcium, and phosphate molecules. The remaining bioceramic structure is naturally metabolized during bone remodeling. This controlled and homogeneous resorption process prevents bulk degradation and chronic inflammation⁷.
Repair
Engineer functional
devices to repair defects
Regenerate
Provide cell energy for
tissue regeneration
Resorb
Resorb without chronic inflammation
CITREGEN Biocompatibility
A sheep study at Colorado State University showed evidence of biocompatibility and biologic ingrowth into porous CITREGEN implants, absent of any signs of chronic inflammation.⁷
CITREGEN History
CITREGEN Healing
CITREGEN activates key genetic pathways for metabolism, osteoconduction, and osteoinduction. Analysis of mesenchymal stem cells showed upregulation of growth factor signaling and bone formation markers, confirming a direct role in tissue regeneration.⁸
In animal models, CITREGEN improved peri-implant integration and pull-out strength compared to controls. These findings highlight its ability to enhance healing at both the cellular and mechanical levels.
7. Acuitive Technologies. Citregen Biological Assessment. Document No. VP1601-VR01.
8. Wang T, et al. A functionalized scaffold with enhanced osteoinductivity promotes bone regeneration. Bioactive Materials. 2016;1(2):132-142.
9. Li Z, et al. Acute tear versus chronic degeneration: citrate metabolism distinguishes human rotator cuff pathologies. Journal of Clinical Investigation. 2019;129(12):5389–5401.